Will Psychology Serve as the Foundation for Sustainable Metabolic Psychiatry?

Emotional Eating BreakThrough! Course

Mental and Metabolic Health Disorders are Bidirectional and Inseparable

Metabolic psychiatry is an exciting and emerging field presently exploring the restorative effects of nutrition in the scope of treatment for serious mental health disorders. The foundation for metabolic psychiatry rests on the past few hundred thousand years of human evolution when significant shifts in nutrition (increased protein and energy dense fat) and food preparation (cooking with fire) allowed for relatively rapid brain growth and development. If we fast-forward through 300,000 years to the past 50 years, we observe a significant reversal in nutrition (increased sugars) as well as food preparation (ultra-processed). It’s not surprising that with this relatively recent reversal, more than half the US adult population are now suffering with metabolic health disorders (resulting in 1400 premature deaths every day). In many cases, these illnesses and premature deaths are both preventable and treatable. Current lifetime statistics project that 50% of the adult population will experience psychological conditions such as anxiety or depression. By 2030, 50% of the US adult population (130 million) will likely meet the criteria for obesity. This is problematic and exponential; mental and metabolic health disorders are bidirectional and inseparable.

Ketogenic and Low Glycemic Eating Styles Support Brain Functioning

There’s no question from gut-brain studies, studies of neurochemistry, dementia and other brain disorders that ketogenic or similar styles of low glycemic eating, as well as supportive lifestyle practices can help restore brain functioning, quality of life, and longevity. The Greeks understood long ago that “healthy mind in a healthy body” was the key for physical and mental health; longevity and contentment. They set the foundation for modern lifestyle medicine with their focus on nutrition, exercise, rest, stress reduction, social connectivity and moderation. Factors we know support brain functioning and mental health wellness. Metabolic disorders share high cross-over rates with mental health disorders and cognitive functioning. Knowing that mental and metabolic health are bi-directional and inseparable, logic would suggest that people suffering with these challenges would be quick to change their ways in support of longevity, but…the data suggest otherwise.

Information Alone Doesn’t Motivate Change

In part it’s because like ourselves, our patients live outside the neat confines of laboratory science; living and experiencing life through unpredictable, or even messy social dynamics that uniquely and deeply influence perception, beliefs, and behaviors. We are seldom motivated to make significant behavioral changes based on information alone. Motivation that inspires consistent lifestyle or behavioral change rests on introspection; the process of evaluating or exploring how new information aligns with our beliefs or values, that in turn drives or guides our behavior. Introspection is the process that ultimately yields actionable insight. Actionable insight can be thought of as the catalyst that informs and inspires our willingness to consistently realign impulsive or past behaviors with our present strengths, values and goals. In time, consistency helps us develop new routines that overcome our brain’s deep-seated resistance to change.

Mental Health Disorders Often Undermine Behavioral Change

Active mental health disorders such as anxiety, depression, trauma, relationship problems, attention deficit disorders, and addiction (to name a few) often undermine an individual’s efforts at implementing sustainable behavioral change. If we’ve learned anything from addiction medicine, it’s that unchecked; past triggers, (emotional or cue-induced) impulsively prompt past behaviors. It’s my humble opinion that for many of our patients, psychological support, guided introspection, as well as retraining the reward center of the brain, will be fundamental to the success of metabolic psychiatry. I’m not entirely alone in this line of thought. With the advent of GLP-1 prescribing for the treatment of obesity, and the rapid weight regain following discontinuation, in its December 2025 guidelines, the World Health Organization (WHO) made the recommendation that weekly counseling sessions with a therapist (one-on-one, or in groups) is an important component of intensive behavioral therapy.

The Patient as Primary Stakeholder

It takes a cross section of providers to satisfy the holistic elements of integrated care. That said, for mental and behavioral health recovery, we support your patients with the mental health support and encouragement to become the primary stakeholder in their own recovery. This transition is achieved through cognitive restructuring and other therapeutic modalities designed to challenge perceptions such as low self-efficacy and self-worth, as well as negative emotions and unhealthy behaviors.

Empower Your Patients

BreakThrough! courses are structured to put the hard work of recovery on the clients and help alleviate provider burn-out. Whether patients use the course workbook (with over 170 topics and 560 introspective exercises) with provider supervision, or our weekly online groups, the client becomes the stakeholder in their recovery! We hope you’ll take a close look at how BreakThrough! and our innovative resources may be integrated into your organization or practice to help your patients achieve sustainable tools for recovery.

Dr. Heather Hamilton

Founder Team BreakThrough!

References

 

  1. Ward, Z. J., Bleich, S. N., Cradock, A. L., Barrett, J. L., Giles, C. M., Flax, C., Long, M. W., & Gortmaker, S. L. (2019). Projected U.S. State-Level Prevalence of Adult Obesity and Severe Obesity. The New England journal of medicine, 381(25), 2440–2450. https://doi.org/10.1056/NEJMsa1909301
  2. Center for Disease control and Prevention. (2023). Adult Obesity. Retrieved from: https://www.cdc.gov/obesity/data/adult.html
  3. Sandhu S, Sharma A, Cholera R, Bettger JP. Integrated Health and Social Care in the United States: A Decade of Policy Progress. Int J Integr Care. 2021 Oct 29;21(4):9. doi: 10.5334/ijic.5687. PMID: 34785994; PMCID:MC8570194.
  4. World Obesity Federation. (2019). Economic Impact of overweight and obesity. https://data.worldobesity.org/economic-impact-new/countries/#US
  5. Center for Disease control and Prevention. (2023). Disability and Obesity. Retrieved from: https://www.cdc.gov/disability-and-health/conditions/obesity.html
  6. National Institute for Health. (2023). Mental Illness. https://www.nimh.nih.gov/health/statistics/mental-illness
  7. National alliance for Mental Illness. (2023). Mental health by the numbers. Retrieved from: https://www.nami.org/mhstats
  8. Hall, K. D., & Kahan, S. (2018). Maintenance of Lost Weight and Long-Term Management of Obesity. The Medical clinics of North America, 102(1), 183–197. https://doi.org/10.1016/j.mcna.2017.08.012
  9. Fildes, A., Charlton, J., Rudisill, C., Littlejohns, P., Prevost, A. T., & Gulliford, M. C. (2015). Probability of an Obese Person Attaining Normal Body Weight: Cohort Study Using Electronic Health Records. American journal of public health, 105(9), e54–e59. https://doi.org/10.2105/AJPH.2015.302773

10        Tzang, C. C., Wu, P. H., Luo, C. A., Chen, Z. T., Lee, Y. T., Huang, E. S., Kang, Y. F., Lin, W. C., Tzang, B. S., & Hsu, T. C. (2025). Metabolic rebound after GLP-1 receptor agonist discontinuation: a systematic review and meta-analysis. EClinicalMedicine, 90, 103680. https://doi.org/10.1016/j.eclinm.2025.103680

  1. Berg, S., Stickle, H., Rose, S. J., & Nemec, E. C. (2025). Discontinuing glucagon-like peptide-1 receptor agonists and body habitus: A systematic review and meta-analysis. Obesity reviews : an official journal of the International Association for the Study of Obesity, 26(8), e13929. https://doi.org/10.1111/obr.1392 
    1. Hamilton, H. (2015; 2017; 2018, 2023) BreakThrough!
    2. Miller, W. R., & Rollnick, S. (2002). Motivational interviewing: Preparing people for change (2nd ed.). The Guilford Press..
    3. Graham, S. (2023) Narcissistic Personality disorder and empathy. Retrieved from: https://childrenofnarcissists.org.uk/narcissistic-personality-disorder-and-empathy/
    4. Baskin-Sommers, A., Krusemark, E., & Ronningstam, E. (2014). Empathy in narcissistic personality disorder: from clinical and empirical perspectives. Personality disorders, 5(3), 323–333. https://doi.org/10.1037/per0000061
    5. Leung, S. E., Wnuk, S., Jackson, T., Cassin, S. E., Hawa, R., & Sockalingam, S. (2019). Prospective Study of Attachment as a Predictor of Binge Eating, Emotional Eating and Weight Loss Two Years after Bariatric Surgery. Nutrients, 11(7), 1625. https://doi.org/10.3390/nu11071625
    6. Graham, S. (2023) Narcissistic Personality disorder and empathy. Retrieved from: https://childrenofnarcissists.org.uk/narcissistic-personality-disorder-and-empathy/
    7. Baskin-Sommers, A., Krusemark, E., & Ronningstam, E. (2014). Empathy in narcissistic personality disorder: from clinical and empirical perspectives. Personality disorders, 5(3), 323–333. https://doi.org/10.1037/per0000061
    8. The Attachment Project. (2023) Understanding addiction through attachment theory. Retrieved from: https://www.attachmentproject.com/blog/addiction-and-attachment-theory/
    9. Monteleone, A. M., Patriciello, G., Ruzzi, V., Fico, G., Pellegrino, F., Castellini, G., Steardo, L., Jr, Monteleone, P., & Maj, M. (2018). Insecure Attachment and Hypothalamus-Pituitary-Adrenal Axis Functioning in People With Eating Disorders. Psychosomatic medicine, 80(8), 710–716. https://doi.org/10.1097/PSY.0000000000000629
    10. Hoffman, R. (2023) Alfred Adler’s Theories of individual psychology and Adlerian therapy. Retrieved from: https://www.simplypsychology.org/alfred-adler.html
    11. Fonseca, A. L., Koyama, J., & Butler, E. A. (2018). The Role of Family of Origin in Current Lifestyle Choices: A Qualitative Secondary Data Analysis of Interracial and Same-Race Couples. Family & community health, 41(3), 146–158. https://doi.org/10.1097/FCH.0000000000000188
    12. Kouvonen A, Stafford M, De Vogli R, Shipley MJ, Marmot MG, Cox T, Vahtera J, Väänänen A, Heponiemi T, Singh-Manoux A, Kivimäki M. (2010) Negative aspects of close relationships as a predictor of increased body mass index and waist circumference: the Whitehall II study. Am J Public Health. 2011 Aug;101(8):1474-80. doi: 10.2105/AJPH.2010.300115. Epub 2011 Jun 16. PMID: 21680928; PMCID: PMC3134502.
    13. Marianna Virtanen, Jussi Vahtera, Archana Singh-Manoux, Marko Elovainio, Jane E. Ferrie, Mika Kivimäki,. Unfavorable and favorable changes in modifiable risk factors and incidence of coronary heart disease: The Whitehall II cohort study, International Journal of Cardiology, Volume 269,2018,Pages 7-12,ISSN 0167-5273, https://doi.org/10.1016/j.ijcard.2018.07.005.
    14. Kouvonen, A., Stafford, M., De Vogli, R., Shipley, M. J., Marmot, M. G., Cox, T., Vahtera, J., Väänänen, A., Heponiemi, T., Singh-Manoux, A., & Kivimäki, M. (2011). Negative aspects of close relationships as a predictor of increased body mass index and waist circumference: the Whitehall II study. American journal of public health, 101(8), 1474–1480. https://doi.org/10.2105/AJPH.2010.300115
    15. Berne, E. (1957). Ego states in psychotherapy. American journal of psychotherapy, 11(2), 293-309.
    16. Murray, H. (2023) Transactional Analysis Theory & Therapy: Eric Berne. Retrieved from: https://www.simplypsychology.org/transactional-analysis-eric-berne.html
    17. Kurnik Mesarič, K., Pajek, J., Logar Zakrajšek, B. et al. Cognitive behavioral therapy for lifestyle changes in patients with obesity and type 2 diabetes: a systematic review and meta-analysis. Sci Rep 13, 12793 (2023). https://doi.org/10.1038/s41598-023-40141-5
    18. Ellis, A. (2001) Overcoming Destructive Beliefs, Feelings, and Behaviors: New Directions for Rational Emotive Behavior Therapy; Prometheus ISBN1-57392-879-8
    19. Kabat-Zinn, J. (1990) Mindfulness Based Stress Reduction. Full catastrophe living: Using the wisdom of your body and mind to face stress, pain, and illness. New York, NY: Delta
    20. Linehan, M.M. (1993). Cognitive-Behavioral Treatment of Borderline Personality Disorder. New York, NY: Guilford Press.
    21. Mothersill, K. (2016). Enhancing positivity in cognitive behavioural therapy. Canadian Psychology/Psychologie Canadienne, 57(1), 1
    22. Price C.J. & Hooven, C. (2018). Interoceptive awareness skills for emotion regulation: Theory and approach of mindful awareness in body-oriented therapy (MABT). Front. Psychol., 27 May 2018 Sec. Emotion Science. Volume 9 – 2018 | https://doi.org/10.3389/fpsyg.2018.00798. Retrieved from:

    https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2018.00798/full

    1. Moore, T. (1992) Care of the Soul. New York, NY: Harper Collins
    2. Chapter Two References

       

        1. Pacheco, D. Rehman, A. (2023). Drowsy driving vs. drunk driving: how similar are they? https://www.sleepfoundation.org/drowsy-driving/drowsy-driving-vs-drunk-driving.
        2. UCLA Health. (2023) Sleep disorders: heart disease. Retrieved from: https://www.uclahealth.org/medical-services/sleep-disorders/patient-resources/patient-education/heart-disease
        3. Palmer, C. (2022). Brain Energy: A Revolutionary Breakthrough in Understanding Mental Health–and Improving Treatment for Anxiety, Depression, OCD, PTSD, and More. BenBella Books.
        4. Cooper, C. B., Neufeld, E. V., Dolezal, B. A., & Martin, J. L. (2018). Sleep deprivation and obesity in adults: a brief narrative review. BMJ open sport & exercise medicine, 4(1), e000392. https://doi.org/10.1136/bmjsem-2018-000392
        5. Vyas, N, Suni, E. (2023). How lack of sleep impacts cognitive performance and focus. Retrieved from: https://www.sleepfoundation.org/sleep-deprivation/lack-of-sleep-and-cognitive-impairment
        6. UCLA Health. (2023) Sleep disorders: heart disease. Retrieved from: https://www.uclahealth.org/medical-services/sleep-disorders/patient-resources/patient-education/heart-disease
        7. Newsom, R., Singh, A. (2023) Obstructive Sleep Apnea. What it is, how to recognize it, why it matters, and how it can be treated. Retrieved from: https://www.sleepfoundation.org/sleep-apnea/obstructive-sleep-apnea
        8. Dedhia, P., t Maurer,R.(2022). Sleep and Health – A Lifestyle Medicine Approach. American College of Lifestyle Medicine.doi: 10.12788/jfp.0295. Retrived from https://www.google.com/search?client=firefox-b-1-d&q=sleep+tips+Lifestyle+Medicine
        9. 5 Shokri-Kojori, E., Wang, G. J., Wiers, C. E., Demiral, S. B., Guo, M., Kim, S. W., Lindgren, E., Ramirez, V., Zehra, A., Freeman, C., Miller, G., Manza, P., Srivastava, T., De Santi, S., Tomasi, D., Benveniste, H., & Volkow, N. D. (2018). β-Amyloid accumulation in the human brain after one night of sleep deprivation. Proceedings of the National Academy of Sciences of the United States of America, 115(17), 4483–4488. https://pubmed.ncbi.nlm.nih.gov/29632177/
        10. Stanford University https://longevity.stanford.edu/lifestyle/lifestyle-pillars/lifestyle-medicine-sleep/Stanford.
        11. Noordam, R., Ramkisoensing, A., Loh, N. Y., Neville, M. J., Rosendaal, F. R., Willems van Dijk, K., van Heemst, D., Karpe, F., Christodoulides, C., & Kooijman, S. (2019). Associations of Outdoor Temperature, Bright Sunlight, and Cardiometabolic Traits in Two European Population-Based Cohorts. The Journal of clinical endocrinology and metabolism, 104(7), 2903–2910. https://doi.org/10.1210/jc.2018-02532
        12. Kuckuck S, van der Valk ES, Scheurink AJW, van der Voorn B, Iyer AM, Visser JA, Delhanty PJD, van den Berg SAA, van Rossum EFC. Glucocorticoids, stress and eating: The mediating role of appetite-regulating hormones. Obes Rev. 2023 Mar;24(3):e13539. doi: 10.1111/obr.13539. Epub 2022 Dec 8. PMID: 36480471; PMCID: PMC10077914.
        13. American Psychological Association. (2023, March 8). Stress effects on the body. https://www.apa.org/topics/stress/body
        14. Weltens, N., Zhao, D., & Van Oudenhove, L. (2014). Where is the comfort in comfort foods? Mechanisms linking fat signaling, reward, and emotion. Neurogastroenterology & Motility, 26(3), 303-315.
        15. Uncapher, M. R., Lin, L., Rosen, L. D., Kirkorian, H. L., Baron, N. S., Bailey, K., Cantor, J., Strayer, D. L., Parsons, T. D., & Wagner, A. D. (2017). Media Multitasking and Cognitive, Psychological, Neural, and Learning Differences. Pediatrics, 140(Suppl 2), S62–S66. https://doi.org/10.1542/peds.2016-1758D
        16. Vedechkina, M., & Borgonovi, F. (2021). A review of evidence on the role of digital technology in shaping attention and cognitive control in children. Frontiers in Psychology, 12, 611155.8 Lee, C. R., Chen, A., & Tye, K. M. (2021). The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation. Cell, 184(6), 1500–1516. https://doi.org/10.1016/j.cell.2021.02.028Lee,
        17. Christopher R. et al. The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation Cell, Volume 184, Issue 6, 1500 – 1516
        18. Li, W., Wang, Z., Syed, S., Lyu, C., Lincoln, S., O’Neil, J., Nguyen, A. D., Feng, I., & Young, M. W. (2021). Chronic social isolation signals starvation and reduces sleep in Drosophila. Nature, 597(7875), 239–244. https://doi.org/10.1038/s41586-021-03837-0
        19. Buettner, D. (2023) How to live to 100: The Secrets of Blue Zones. Netflix series. https://www.netflix.com/title/81214929
        20. Appelhans, B. M., Whited, M. C., Schneider, K. L., Oleski, J., & Pagoto, S. L. (2011). Response style and vulnerability to anger-induced eating in obese adults. Eating behaviors, 12(1), 9–14. https://doi.org/10.1016/j.eatbeh.2010.08.009
        21. Thoele, S.P. (2022). The courage to be yourself: a woman’s guide to emotional strength and self-esteem. Mango Publishing. ISBN-13  978-1-68481-026-0 Available from: https://www.amazon.com/Courage-Be-Yourself-Emotion
        22. 1.              
          Deputy, N. P., Dub, B., &
          Sharma, A. J. (2018). Prevalence and Trends in Pre-pregnancy Normal Weight – 48
          States, New York City, and District of Columbia, 2011-2015. MMWR. Morbidity
          and mortality weekly report
          , 66(51-52), 1402–1407.
          https://doi.org/10.15585/mmwr.mm665152a3

          2.              
          Ceasrine, A. M., & Bilbo, S.
          D. (2022). Dietary fat: a potent microglial influencer. Trends in
          endocrinology and metabolism: TEM
          , 33(3), 196–205.
          https://doi.org/10.1016/j.tem.2021.12.005

          3.              
          Edlow A. G. (2017). Maternal obesity and
          neurodevelopmental and psychiatric disorders in offspring. Prenatal
          diagnosis
          , 37(1), 95–110.
          https://doi.org/10.1002/pd.4932

          4.              
          Gómez-Apo, E., Mondragón-Maya, A.,
          Ferrari-Díaz, M., & Silva-Pereyra, J. (2021). Structural Brain Changes
          Associated with Overweight and Obesity. Journal of obesity, 2021,
          6613385.
          https://doi.org/10.1155/2021/6613385

          5.              
           B. Y.,
          Yao, R., Tierney, E., Brucato, M., Hong, X., Wang, G., Ji, Y., Pearson, C.,
          Fallin, M. D., Wang, X., & Volk, H. (2021). The association between
          maternal lipid profile after birth and offspring risk of autism spectrum
          disorder. Annals of epidemiology, 53, 50–55.e1.
          https://doi.org/10.1016/j.annepidem.2020.08.009

          6.              
          Palmer, C.
          (2021). A Mother’s diet may affect her child’s mental health.    
          https://www.psychologytoday.com/us/blog/advancing-psychiatry/202109/mother-s-diet-may-affect-her-child-s-mental-health.

          7.              
          Sullivan, E. L., Nousen, E. K., & Chamlou, K. A.
          (2014).
          Maternal high fat diet consumption during the
          perinatal period programs offspring behavior. Physiology & behavior,
          123, 236–242.
          https://doi.org/10.1016/j.physbeh.2012.07.014

          8.              
          Weltens, N., Zhao, D., & Van Oudenhove, L. (2014). Where
          is the comfort in comfort foods? Mechanisms linking fat signaling, reward, and
          emotion. Neurogastroenterology & Motility, 26(3), 303-315.

          9.              
          Ali, N., Katsouli, J., Marczylo, E. L., Gant,
          T. W., Wright, S., & Bernardino de la Serna, J. (2024). The potential
          impacts of micro-and-nano plastics on various organ systems in humans. EBioMedicine,
          99, 104901.
          https://doi.org/10.1016/j.ebiom.2023.104901

          10.           
          Décarie-Spain, L.,
          Gu, C., Tierno Lauer, L. et al. Ventral hippocampus neurons encode
          meal-related memory. Nat Commun 16, 4898 (2025).
          https://doi.org/10.1038/s41467-025-59687-1

          11.           
          Ziauddeen, H., Chamberlain, S. R., Nathan, P.
          J., Koch, A., Maltby, K., Bush, M., Tao, W. X., Napolitano, A., Skeggs, A. L.,
          Brooke, A. C., Cheke, L., Clayton, N. S., Sadaf Farooqi, I., O’Rahilly, S.,
          Waterworth, D., Song, K., Hosking, L., Richards, D. B., Fletcher, P. C., &
          Bullmore, E. T. (2013). Effects of the mu-opioid receptor antagonist GSK1521498
          on hedonic and consummatory eating behaviour: a proof of mechanism study in
          binge-eating obese subjects. Molecular psychiatry, 18(12), 1287–1293.
          https://doi.org/10.1038/mp.2012.154

          12.           
          DiNicolantonio, J. J., &
          O’Keefe, J. (2021). The Importance of Maintaining a Low Omega-6/Omega-3 Ratio
          for Reducing the Risk of Autoimmune Diseases, Asthma, and Allergies. Missouri
          medicine, 118(5), 453–459.

          13.           
          Watson, K. T., Simard, J. F.,
          Henderson, V. W., Nutkiewicz, L., Lamers, F., Nasca, C., Rasgon, N., &
          Penninx, B. W. J. H. (2021). Incident Major Depressive Disorder Predicted by
          Three Measures of Insulin Resistance: A Dutch Cohort Study. The American
          journal of psychiatry, 178(10), 914–920.
          https://doi.org/10.1176/appi.ajp.2021.20101479

          14.           
          Gonnissen, H.
          J., Hulshof, T., & Westerterp-Plantenga, M. S. (2013). Chronobiology,
          endocrinology, and energy- and food-reward homeostasis. Obesity Reviews: An
          Official Journal of the International Association for the Study of Obesity,
          14(5), 405-416. doi:10.1111/obr.12019

          15.           
          Morales I. (2022). Brain regulation of hunger
          and motivation: The case for integrating homeostatic and hedonic concepts and
          its implications for obesity and addiction. Appetite, 177,
          106146.
          https://doi.org/10.1016/j.appet.2022.1061

          16.           
          Wang, Y.,
          Leung, V. H., Zhang, Y., Nudell, V. S., Loud, M., Servin-Vences, M. R., Yang,
          D., Wang, K., Moya-Garzon, M. D., Li, V. L., Long, J. Z., Patapoutian, A.,
          & Ye, L. (2022). The role of somatosensory innervation of adipose tissues. Nature,
          609(7927), 569–574. https://doi.org/10.1038/s41586-022-05137-7

          17.           
          Miranda, K.,
          Mehrpouya-Bahrami, P., Nagarkatti, P.S. and Nagarkatti, M. (2019).
          Cannabinoid Receptor 1 Blockade Attenuates
          Obesity and Adipose Tissue Type 1 Inflammation Through miR-30e-5p Regulation of
          Delta-Like-4 in Macrophages and Consequently Downregulation of Th1 Cells
          Front. Immunol., 10 May 2019Sec.
          Inflammation Volume 10 – 2019 |
          https://doi.org/10.3389/fimmu.2019.01049

          18.           
          Lomonaco, R.,
          Godinez Leiva, E., Bril, F., Shrestha, S., Mansour, L., Budd, J., Portillo
          Romero, J., Schmidt, S., Chang, K. L., Samraj, G., Malaty, J., Huber, K.,
          Bedossa, P., Kalavalapalli, S., Marte, J., Barb, D., Poulton, D., Fanous, N.,
          & Cusi, K. (2021). Advanced Liver Fibrosis Is Common in Patients With Type
          2 Diabetes Followed in the Outpatient Setting: The Need for Systematic
          Screening. Diabetes care, 44(2), 399–406.
          https://doi.org/10.2337/dc20-1997

          19.           
          Dutta,
          B. J., Singh, S., Seksaria, S., Das Gupta, G., & Singh, A. (2022). Inside
          the diabetic brain: Insulin resistance and molecular mechanism associated with
          cognitive impairment and its possible therapeutic strategies. Pharmacological
          research
          , 182, 106358. https://doi.org/10.1016/j.phrs.2022.106358

          20.           
          Park, B. Y.,
          Yao, R., Tierney, E., Brucato, M., Hong, X., Wang, G., Ji, Y., Pearson, C.,
          Fallin, M. D., Wang, X., & Volk, H. (2021). The association between
          maternal lipid profile after birth and offspring risk of autism spectrum
          disorder. Annals of epidemiology, 53, 50–55.e1.
          https://doi.org/10.1016/j.annepidem.2020.08.009

          21.           
          Hesse, S.,
          van de Giessen, E., Zientek, F., Petroff, D., Winter, K., Dickson, J. C.,
          Tossici-Bolt, L., Sera, T., Asenbaum, S., Darcourt, J., Akdemir, U. O.,
          Knudsen, G. M., Nobili, F., Pagani, M., Vander Borght, T., Van Laere, K.,
          Varrone, A., Tatsch, K., Sabri, O., & Booij, J. (2014). Association of
          central serotonin transporter availability and body mass index in healthy
          Europeans. European neuropsychopharmacology : the journal of the European
          College of Neuropsychopharmacology, 24(8), 1240–1247.
          https://doi.org/10.1016/j.euroneuro.2014.05.005

          22.           
          Yang, M.,
          Singh, A., de Araujo, A. et al. Separate orexigenic hippocampal ensembles shape
          dietary choice by enhancing contextual memory and motivation. Nat Metab 7,
          276–296 (2025).
          https://doi.org/10.1038/s42255-024-01194-6

          22a.      Tzang, C. C., Wu, P. H., Luo, C. A., Chen,
          Z. T., Lee, Y. T., Huang, E. S., Kang, Y. F., Lin, W. C., Tzang, B. S., &
          Hsu, T. C. (2025). Metabolic rebound after GLP-1 receptor agonist
          discontinuation: a systematic review and meta-analysis. EClinicalMedicine,
          90, 103680. https://doi.org/10.1016/j.eclinm.2025.103680

          22b.      Berg, S., Stickle, H., Rose, S. J., &
          Nemec, E. C. (2025). Discontinuing glucagon-like peptide-1 receptor agonists
          and body habitus: A systematic review and meta-analysis. Obesity reviews :
          an official journal of the International Association for the Study of Obesity
          ,
          26(8), e13929. https://doi.org/10.1111/obr.13929

          23.           
          Ludwig, D. S., &
          Ebbeling, C. B. (2018).
          The
          Carbohydrate-Insulin Model of Obesity: Beyond “Calories In, Calories
          Out”. JAMA internal medicine, 178(8), 1098–1103.
          https://doi.org/10.1001/jamainternmed.2018.2933

          24.           
          Gearhardt, A.N., and Hebebrand, J. (2021). The
          concept of “food addiction” helps inform the understanding of overeating and
          obesity: YES, The American Journal of Clinical Nutrition, Volume 113,
          Issue 2, February 2021, Pages 263–267,
          https://doi.org/10.1093/ajcn/nqaa343

          25.           
          Monteiro, C. A., Cannon, G., Levy, R. B., Moubarac, J.
          C., Louzada, M. L., Rauber, F., …
          &
          Jaime, P. C. (2019). Ultra-processed foods: what they are and how to identify
          them. Public health nutrition, 22(5), 936-941

          26.           
          Palmer, C. (2022). Brain Energy: A
          Revolutionary Breakthrough in Understanding Mental Health–and Improving
          Treatment for Anxiety, Depression, OCD, PTSD, and More. BenBella Books.

          27.           
          Collins L,
          Costello RA. Glucagon-Like Peptide-1 Receptor Agonists. [Updated 2024 Feb 29].
          In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025
          Jan-. Available from:
          https://www.ncbi.nlm.nih.gov/books/NBK551568/

          28.           
          Koob, G. F., & Volkow, N. D. (2016).
          Neurobiology of addiction: a neurocircuitry analysis. The lancet. Psychiatry,
          3(8), 760–773. https://doi.org/10.1016/S2215-0366(16)00104-8

          29.           
          Cortese S.
          (2019). The Association between ADHD and Obesity: Intriguing, Progressively
          More Investigated, but Still Puzzling. Brain sciences, 9(10),
          256.
          https://doi.org/10.3390/brainsci9100256

          30.           
          Substance
          Abuse and Mental Health Services Administration (US); Office of the Surgeon
          General (US). Facing Addiction in America: The Surgeon General’s Report on
          Alcohol, Drugs, and Health [Internet]. Washington (DC): US Department of Health
          and Human Services; 2016 Nov. CHAPTER 2, THE NEUROBIOLOGY OF SUBSTANCE USE,
          MISUSE, AND ADDICTION. Available from:
          https://www.ncbi.nlm.nih.gov/books/NBK424849/

          31.           
          Prange, S., Metereau, E., Klinger,
          H., Huddlestone, M., De Oliveira, M., Duperrier, S., Courault, P., Redoute, J.,
          Tremblay, L., Sgambato, V., Lancelot, S., & Thobois, S. (2025).
          Serotonergic dysfunction in patients with impulse control disorders in
          Parkinson’s disease. Brain : a journal of neurology, 148(6),
          2108–2121.
          https://doi.org/10.1093/brain/awaf087

           

          32.           
          Cîmpeanu, R. C., Caragea, E. M., Mustață, L.
          M., Forțofoiu, D., Dragne, I. G., Alexa, R. E., Balta, A., Ceasovschih, A.,
          Șorodoc, L., & Săndulescu, L. D. (2025). The Involvement of Serotonin in
          the Obesity Pathway-A Last Decade Systematic Review of the Literature.
          International journal of molecular sciences, 26(7), 3081.
          https://doi.org/10.3390/ijms26073081

          33.           
          Kaur, H., Bose, C., & Mande, S. S. (2019).
          Tryptophan Metabolism by Gut Microbiome and Gut-Brain-Axis: An in silico
          Analysis. Frontiers in neuroscience, 13, 1365.
          https://doi.org/10.3389/fnins.2019.

          34.           
          Beurel, E., Toups, M., & Nemeroff, C. B.
          (2020). The Bidirectional Relationship of Depression and Inflammation: Double
          Trouble.
          Neuron, 107(2), 234–256.
          https://doi.org/10.1016/j.neuron.2020.06.002 https://www.raysahalian.com/cytokines,html.

          35.           
          Gao, K., Mu, C. L., Farzi, A., & Zhu, W. Y. (2020). Tryptophan
          metabolism: A link between the gut microbiota and brain. Advances in
          nutrition (Bethesda, Md.)
          , 11(3), 709–723.
          https://doi.org/10.1093/advances/nmz127

          36.           
          Asadi, A., Shadab Mehr, N., Mohamadi, M. H.,
          Shokri, F., Heidary, M., Sadeghifard, N., & Khoshnood, S. (2022). Obesity
          and gut-microbiota-brain axis: A narrative review. Journal of clinical
          laboratory analysis
          , 36(5), e24420.
          https://doi.org/10.1002/jcla.24420

          37.           
          Sasso, J. M.,
          Ammar, R. M., Tenchov, R., Lemmel, S., Kelber, O., Grieswelle, M., & Zhou,
          Q. A. (2023). Gut Microbiome-Brain Alliance: A Landscape View into Mental and
          Gastrointestinal Health and Disorders. ACS chemical neuroscience, 14(10),
          1717–1763.
          https://doi.org/10.1021/acschemneuro.3c00127

          38.           
          Kurowska
          A, Ziemichód W, Herbet M, Piątkowska-Chmiel I. The Role of Diet as a Modulator
          of the Inflammatory Process in the Neurological Diseases. Nutrients. 2023 Mar
          16;15(6):1436. doi: 10.3390/nu15061436. PMID: 36986165; PMCID: PMC10057655.

          39.           
          Cherry, K.
          (2023). How does the nervous system work with the endocrine system? Retrieved
          from:
          https://www.verywellmind.com/the-nervous-and-endocrine-systems-2794894

          40.           
          Ju, W.
          (2023).The endocrine system. Retrieved from:
          https://www.verywellmind.com/the-nervous-and-endocrine-systems-2794894
          https://ecampusontario.pressbooks.pub/neurosciencecdn/chapter/anatomy-physiology-the-endocrine-system/

          41.           
          Barth, C., Villringer, A., & Sacher, J.
          (2015). Sex hormones affect neurotransmitters and shape the adult female brain
          during hormonal transition periods. Frontiers in neuroscience, 9,
          37. https://doi.org/10.3389/fnins.2015.00037

          42.           
          Mishra S, Elliott H, Marwaha R. Premenstrual
          Dysphoric Disorder. [Updated 2023 Feb 19]. In: StatPearls [Internet]. Treasure
          Island (FL): StatPearls Publishing; 2023 Jan-. Available from:
          https://www.ncbi.nlm.nih.gov/books/NBK532307

          43.           
          Kempuraj D, Thangavel R, Selvakumar GP, Zaheer
          S, Ahmed ME, Raikwar SP, Zahoor H, Saeed D, Natteru PA, Iyer S, Zaheer A. Brain
          and Peripheral Atypical Inflammatory Mediators Potentiate Neuroinflammation and
          Neurodegeneration. Front Cell Neurosci. 2017 Jul 24;11:216. doi:
          10.3389/fncel.2017.00216. PMID: 28790893; PMCID: PMC5522882.

          44.           
          Adamu,
          A., Li, S., Gao, F., & Xue, G. (2024). The role of neuroinflammation in
          neurodegenerative diseases: current understanding and future therapeutic
          targets. Frontiers in aging neuroscience, 16, 1347987.
          https://doi.org/10.3389/fnagi.2024.1347987

          45.           
          Rhie,
          S. J., Jung, E. Y., & Shim, I. (2020). The role of neuroinflammation on
          pathogenesis of affective disorders. Journal of exercise rehabilitation, 16(1),
          2–9.
          https://doi.org/10.12965/jer.2040016.008

          46.           
          Sager,
          J. (2022) What Is the Glycemic Index? Purpose and
          Limitations
          .
          https://www.healthgrades.com/right-care/food-nutrition-and-diet/glycemic-index?tpc=latest-news&cid=63emHLN091922NUTV3

          47.           
          Vega-López, S., Venn, B. J., & Slavin, J.
          L. (2018). Relevance of the Glycemic Index and Glycemic Load for Body Weight,
          Diabetes, and Cardiovascular Disease. Nutrients, 10(10), 1361.
          https://doi.org/10.3390/nu10101361

          48.           
          Mollica, M. P., Mattace
          Raso, G., Cavaliere, G., Trinchese, G., De Filippo, C., Aceto, S., Prisco, M.,
          Pirozzi, C., Di Guida, F., Lama, A., Crispino, M., Tronino, D., Di Vaio, P.,
          Berni Canani, R., Calignano, A., & Meli, R. (2017).
          Butyrate Regulates Liver Mitochondrial
          Function, Efficiency, and Dynamics in Insulin-Resistant Obese Mice. Diabetes,
          66(5), 1405–1418.
          https://doi.org/10.2337/db16-0924

          49.           
          Attia, P. & Gifford, B. (2023). Outlive: The Science and Art of Longevity.

          50.           
          Baker, M. (2022) Everything You Need to Know About
          Diabetes.
          https://www.healthgrades.com/right-care/diabetes/diabetes?tpc=latest-news

          51.           
          Wardelmann,
          K., Blümel, S., Rath, M., Alfine, E., Chudoba, C., Schell, M., Cai, W., Hauffe,
          R., Warnke, K., Flore, T., Ritter, K., Weiß, J., Kahn, C. R., &
          Kleinridders, A. (2019). Insulin action in the brain regulates mitochondrial
          stress responses and reduces diet-induced weight gain. Molecular metabolism,
          21, 68–81.
          https://doi.org/10.1016/j.molmet.2019.01.001

          52.           
          Goodpaster, B. H., & Sparks, L. M. (2017).
          Metabolic Flexibility in Health and Disease. Cell metabolism, 25(5),
          1027–1036.
          https://doi.org/10.1016/j.cmet.2017.04.015

          53.           
          Tsui, B. (2022). How do strong muscles keep your brain healthy?
          Retrieved from:
          https://www.technologyreview.com/2022/08/22/1057660/strong-muscles-healthy-brain/

          54.           
          Zhang, H., Wu, X., Liang,
          J., Kirberger, M., & Chen, N. (2022).
          Irisin, an exercise-induced bioactive peptide
          beneficial for health promotion during aging process. Ageing research
          reviews
          , 80, 101680. https://doi.org/10.1016/j.arr.2022.101680

          55.           
          Joseph, R.J., Alonso,M.,
          Bond, D.S., Pascual-Leone, A., & Blackburn, G.L. (2011). The neurocognitive
          connection between physical activity and eating behavior. Obesity Reviews: an
          Official Journal of the International Association for the study of Obesity.
          12(10), 800-812. Doi: 10.1111/j.1467-789X.2011.00893.x

          56.           
          Teixeira, P.J., Mata,
          J., Silva, M. N., Vieira, P. N., Carraça, E. V., Andrade, A. M., Coutinho, S.
          R., & …
          (2011).
          Motivational “spill-over” during weight control: Increased self-determination
          and exercise intrinsic motivation predict eating self-regulation. Sport,
          Exercise, And Performance Psychology, 1(S), 49-59. doi:10.1037/2157-3905.1.S.49

          57.           
          Pesta,
          D. H., Goncalves, R. L. S., Madiraju, A. K., Strasser, B., & Sparks, L. M.
          (2017). Resistance training to improve type 2 diabetes: working toward a
          prescription for the future. Nutrition & metabolism, 14, 24.
          https://doi.org/10.1186/s12986-017-0173-7

          58.           
          Meerman R, Brown A J. When somebody loses
          weight, where does the fat go? BMJ 2014; 349 :g7257 doi:10.1136/bmj.g7257
          Barroso, I., & McCarthy, M. I. (2019). The Genetic Basis of Metabolic
          Disease. Cell, 177(1), 146–161.
          https://doi.org/10.1016/j.cell.2019.02.024

          59.           
          Chung
          N, Park MY, Kim J, Park HY, Hwang H, Lee CH, Han JS, So J, Park J, Lim K.
          Non-exercise activity thermogenesis (NEAT): a component of total daily energy
          expenditure. J Exerc Nutrition Biochem. 2018 Jun 30;22(2):23-30. doi:
          10.20463/jenb.2018.0013. PMID: 30149423; PMCID: PMC6058072.

          60.           
          Levy, J.
          2023. What is adenosine? Benefits for
          heart health, sleep & exercise
          https://draxe.com/nutrition/adenosine/

          61.           
          Jia,
          Q., Tan, H., Li, T., & Duan, X. (2025). Role of adenosine in the
          pathophysiology and treatment of attention deficit hyperactivity disorder.
          Purinergic signalling, 21(4), 841–849.
          https://doi.org/10.1007/s11302-024-10059-2

          62.           
          Hall KD. Physiology
          of the Weight Loss Plateau after Calorie Restriction, GLP-1 Receptor Agonism,
          and Bariatric Surgery. bioRxiv [Preprint]. 2023 Nov 5:2023.11.05.565699. doi:
          10.1101/2023.11.05.565699. PMID: 38076965; PMCID: PMC10705578.

          63.           
          Murray, G. K., Lin,
          T., Austin, J., McGrath, J. J., Hickie, I. B., & Wray, N. R. (2021). Could
          Polygenic Risk Scores Be Useful in Psychiatry?: A Review. JAMA psychiatry,
          78(2), 210–219.
          https://doi.org/10.1001/jamapsychiatry.2020.3042

          64.           
          Anderson, J., Ozan,
          E., Chouinard, VA. et al. The Ketogenic Diet as a Transdiagnostic Treatment for
          Neuropsychiatric Disorders: Mechanisms and Clinical Outcomes. Curr Treat
          Options Psych 12, 1 (2025). https://doi.org/10.1007/s40501-024-00339-4

          65.           
          Paoli, A., Bosco, G.,
          Camporesi, E. M., & Mangar, D. (2015).
          Ketosis, ketogenic diet and food intake
          control: a complex relationship. Frontiers in psychology, 6, 27.
          https://doi.org/10.3389/fpsyg.2015.00027

          66.           
          Liśkiewicz,
          D., Liśkiewicz, A., Nowacka-Chmielewska, M. M., Grabowski, M., Pondel, N.,
          Grabowska, K., Student, S., Barski, J. J., & Małecki, A. (2021).
          Differential Response of Hippocampal and Cerebrocortical Autophagy and Ketone
          Body Metabolism to the Ketogenic Diet. Frontiers in cellular neuroscience, 15,
          733607.
          https://doi.org/10.3389/fncel.2021.733607

          67.           
          Luong,
          T. V., Hansen, K. V., Hansen, A. K., Cunnane, S. C., Møller, N., Søndergaard,
          E., Gormsen, L. C., & Svart, M. (2025). A 3-Week Ketogenic Diet Increases
          Global Cerebral Blood Flow and Brain-Derived Neurotrophic Factor. The Journal
          of clinical endocrinology and metabolism, 110(12), e4176–e4181.
          https://doi.org/10.1210/clinem/dgaf207. 

          67b.      Fraile-Martínez, Ó., Ortega, M. A., &
          García-Montero, C. (2026). Understanding the Secular Decline in Testosterone:
          Mechanisms, Consequences, and Clinical Perspectives. International journal
          of molecular sciences
          , 27(2), 692.
          https://doi.org/10.3390/ijms27020692

          68.           
          Kinmonth,
          L., Griffin, J.. (2021).  Primary care
          experience and remission of type 2 diabetes: a population-based prospective
          cohort study, Family Practice, Volume 38, Issue 2, Pages 140–145
          doi.org/10.1093/fampra/cmaa086

          69.           
          Anderson,
          J., Ozan, E., Chouinard, VA. et al. The Ketogenic Diet as a Transdiagnostic
          Treatment for Neuropsychiatric Disorders: Mechanisms and Clinical Outcomes.
          Curr Treat Options Psych 12, 1 (2025).
          https://doi.org/10.1007/s40501-024-00339-4

          70.           
          World Health
          Organization. (2023)
          WHO
          advises not to use non-sugar sweeteners for weight control in newly released
          guideline. Retrieved from:
          https://www.who.int/news/item/15-05-2023-who-advises-not-to-use-non-sugar-sweeteners-for-weight-control-in-newly-released-guideline.

          71.           
          Rodriguez-Palacios,
          A., Harding, A., Menghini, P., Himmelman, C., Retuerto, M., Nickerson, K. P.,
          Lam, M., Croniger, C. M., McLean, M. H., Durum, S. K., Pizarro, T. T.,
          Ghannoum, M. A., Ilic, S., McDonald, C., & Cominelli, F. (2018). The
          Artificial Sweetener Splenda Promotes Gut Proteobacteria, Dysbiosis, and
          Myeloperoxidase Reactivity in Crohn’s Disease-Like Ileitis. Inflammatory
          bowel diseases
          , 24(5), 1005–1020. https://doi.org/10.1093/ibd/izy060

          72.           
          Steffen,
          B.T., Jacobs, D.R., Yi, SY. et al. Long-term aspartame and saccharin intakes
          are related to greater volumes of visceral, intermuscular, and subcutaneous
          adipose tissue: the CARDIA study. Int J Obes 47, 939–947 (2023).
          https://doi.org/10.1038/s41366-023-01336-y

          73.           
          Carlos A
          Monteiro , Arne Astrup, Does the concept of “ultra-processed foods” help inform
          dietary guidelines, beyond conventional classification systems? YES, The
          American Journal of Clinical Nutrition
          , Volume 116, Issue 6, December 2022,
          Pages 1476–1481,
          https://doi.org/10.1093/ajcn/nqac122

          74.           
          Zaraska,
          M. (2023). Food can be literally addictive. New evidence suggests highly
          processed foods resemble drugs of misuse in a number of disturbing ways.
          Retrieved from:
          https://www.scientificamerican.com/article/food-can-be-literally-addictive-new-evidence-suggests/

          75.           
          Coulson, (2025). Most of
          the Foods We Eat Are Ultra-Processed. Are They All Unhealthy?

          Retreived from John
          Hopkins:
          https://publichealth.jhu.edu/2025/what-are-ultra-processed-foods

          76.           
          Barber, T. M., Kabisch,
          S., Pfeiffer, A. F. H., & Weickert, M. O. (2020).
          The Health Benefits of Dietary Fibre. Nutrients,
          12(10), 3209. https://doi.org/10.3390/nu12103209

          77.           
          Arlinghaus,
          K. R., & Johnston, C. A. (2018). The Importance of Creating Habits and
          Routine. American journal of lifestyle medicine, 13(2), 142–144.
          https://doi.org/10.1177/1559827618818044

          78.           
          World
          Health Organization. Adherence to Long-Term Therapies: Evidence for Action.
          Geneva, Switzerland: World Health Organization; 2003. [
          Google Scholar]

          79.           
          Pashby, R.
          (2022). Routines and weight maintenance: keeping your health consistent.
          Retrieved from:
          https://www.obesityaction.org/resources/routines-and-weight-maintenance-keeping-your-health-consistent/

          80.           
          Ede, G. (2024). Change your diet, change
          your mind: A powerful plan to improve mood, overcome anxiety, and protect
          memory for a lifetime of optimal mental health
          . Hachette Books.
          https://www.amazon.com/Change-Your-Diet-Mind/dp/1399709127

          81.           
          Amare, A. T., Schubert, K. O.,
          Klingler-Hoffmann, M., Cohen-Woods, S., & Baune, B. T. (2017). The genetic
          overlap between mood disorders and cardiometabolic diseases: a systematic
          review of genome wide and candidate gene studies. Translational psychiatry,
          7(1), e1007. https://doi.org/10.1038/tp.2016.
          Fluyau D, Charlton TE. (2022). Drug Addiction. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK549783

Scroll to Top